Synbiotics Containing Nanoprebiotics: A Novel Therapeutic Strategy to Restore Gut Dysbiosis

A new formulation, nanoprebiotics [e.g., phthalyl pullulan nanoparticles (PPNs)], was demonstrated to enhance the antimicrobial activity of probiotics Lactobacillus plantarum (LP)] in vitro through intracellular stimulation better than that by backbone prebiotics, which are commonly used. In this study, we aimed investigate whether combination would exert distinct effects as synbiotics vivo . Synbiotics combinations LP, pullulan, and PPNs were used experimental treatments a dysbiosis-induced murine model, their restorative effect assessed using pathogen Escherichia coli K99 challenge. Our results showed E. infection suppressed markedly group fed with containing PPNs. addition, decrease serum endotoxin level after treatment suggested reinforcement gut barrier. Comparison groups, including normal control group, increased microbial diversity, is representative parameter healthy status. Furthermore, from alone, additive enrichment several well-known beneficial bacteria such Lactobacillus, Bifidobacterium , other butyrate-producing Faecalibacterium Collectively, our indicate effective at restoring dysbiosis, suppressing pathogenic infection, increasing suggesting have potential be novel strategy for ameliorating dysbiosis infectious diseases.